Boc-(R)-3-Amino-4-(2-choro-phenyl)-butyric acid is an organic compound with the following properties:
Appearance: White crystalline or powdery solid
Melting point: about 120-130 ℃
Molecular formula: C15H20ClNO4
Molecular weight: 309.78g/mol
Boc-(R)-3-Amino-4-(2-chroo-phenyl)-butyric acid is mainly used as a reagent and intermediate in organic synthesis. It can be used in drug synthesis, chiral resolution, ligand synthesis and other reactions. It is an amino acid with a protecting group Boc. The Boc group protecting the hydroxyl group can protect the active group in the reaction to control the selectivity of the reaction.
The method of preparing Boc-(R)-3-Amino-4-(2-chroo-phenyl)-butyric acid can be carried out by the following steps:
1. R-3-amino -4-(2-chlorophenyl) butyric acid reacts with dimethyl carbodiimide (DMF-DMA) in a solvent to generate a propionimide intermediate.
2. Boc protection of the propionimide intermediate can be carried out by adding Boc2O to the reaction using tetramethyldiacetoimide (TMEDA) as a base catalyst in the presence of sodium carbonate hydrate (Na2CO3 · H2O) to form a Boc protected amino acid.
Boc-(R)-3-Amino-4-(2-chloro-phenyl)-butyric acid has limited safety information, you need to pay attention to the following during use:
1. It should avoid contact with skin, eyes and mucous membranes, because it may cause irritation and allergic reactions.
2. in operation and storage should be careful to avoid contact with oxidants, strong acids and strong bases to avoid dangerous reactions.
3. Before use, carefully read and follow the guidelines for the safe use of relevant chemicals, and wear appropriate personal protective equipment, such as laboratory gloves and goggles.
4. during storage, it should be kept in a dry, cool place, away from fire and flammable materials.